High-flow

Aerogen delivers aerosol medication to your patients during high-flow (HF) therapy1



Integrated aerosol delivery

Aerogen delivers integrated aerosol delivery with high-flow1,2

  • Fits in-line with no added flow and no interruption of therapy during administration of medication
  • With Aerogen, the circuit can be maintained during aerosol therapy1 unlike conventional nebulisation methods that require interruption of high-flow to use a facemask or mouthpiece†2 

Survey of worldwide clinical practice of HF and concomitant aerosol therapy in the adult ICU setting

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High-flow, integrated aerosol delivery

Ease of use

Aerogen simplifies the workflow1,2

  • One system throughout a patients' respiratory journey (IMV, NIV, HF, self-ventilating),1 providing continuity of care
  • In studies, in-line aerosol drug delivery has been associated with better comfort†2,‡3,‡4 and improved convenience versus conventional aerosol therapy†2
  • Fully supported product training

Survey of worldwide clinical practice of HF and concomitant aerosol therapy in the adult ICU setting. Conventional aerosol therapy consisted of a vibrating mesh nebuliser, ultrasonic nebuliser or jet nebuliser used with a facemask
A randomised, cross-over study in infants with bronchiolitis comparing in-line Aerogen vs jet nebuliser with a facemask

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Using Aerogen

3 steps


High-flow, 3 steps

Effectiveness

Aerogen facilitates effective medication delivery during HF5–10

In studies, in-line aerosol drug delivery with Aerogen during high-flow was associated with:

  • 4x more medication delivered to the lungs (3.6%) versus a jet nebuliser ( 1.0%)†5
  • 3.5% –17% medication delivery to the lungs, depending on flow rates†6

Aerogen supports bronchodilator response during HF7–10

In studies of patients with COPD or asthma, in-line aerosol drug delivery with Aerogen during high-flow has been associated with:

  • Significant improvements in lung function (FEV1, FVC and PEF) following salbutamol nebulisation via HF versus HF alone in patients with severe exacerbation of COPD9
  • Effective bronchodilator response, even with a gas flow of 50 L/min‡10

Study performed in healthy subjects 
At cumulative doses of 1.5–3.5 mg salbutamol in patients with COPD or asthma
COPD, chronic obstructive pulmonary disease; FEV1 forced expiratory volume in 1 second; FVC, forced vital capacity; PEF, peak expiratory flow

Read the evidence

High-flow, effective medication delivery

Scintigraphy images of pulmonary deposition across different flow rates at 10, 30, and 50 L/min in healthy adults.

Guidelines

Recommended by clinical and scientific societies around the world 

Clinical and scientific societies around the world recommend the use of closed-circuit nebulisers for the management of patients with COVID-19 requiring aerosol drug delivery:

  • GOLD: Science Committee Report 202311
  • AARC: Guidance 202012
  • ISAM: Interim Guidance 202013
  • Spanish Scientific Societies: Expert Clinical Consensus 202014
  • Chinese Thoracic Society: Respiratory Care Committee 202015
  • Indian Society of Critical Care Medicine: Position Statement 202016
  • Indian Chest Society: Guidance 202017

Globally renowned

Aerogen technology has been in use for over 20 years, in more than 75 countries globally and  is associated with over 200 clinical papers and publications.18 Aerogen is the partner of choice for the world's leading ventilator companies for aerosol drug delivery.

High-flow, enquiries

Enquiries

The Aerogen team and our representatives are available globally to answer your questions, provide an online demonstration and place orders

How can we help

High-flow, Non-invasive ventilation

Non-invasive ventilation

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High-flow nasal cannula, discover more

High-flow

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High-flow, self ventilating

Self-ventilating

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  1. Aerogen Solo Instruction Manual
  2. Li J, Tu M, Yang L, et al. Respir Care. 2021;66(9):1416-1424.
  3. Valencia-Ramos J, Miras A, Cilla A, et al. Respir Care 2018;63(7):886–893.
  4. Valencia-Ramos J, Ochoa Sangrador C, García M, et al. Arch Dis Child. 2022;archdischild-2021-323161.
  5. Dugernier J, Hesse M, Jumetz T, et al. J Aerosol Med Pulm Drug Deliv. 2017;30(5):349-358.
  6. Alcoforado L, Ari A, Barcelar JM, et al. Pharmaceutics. 2019;11(7):320.
  7. Reminiac F, Vecellio L, Bodet-Contentin L, et al. Ann Intensive Care. 2018;8(1):128.
  8. Li J, Zhao M, Hadeer M, Luo J, Fink JB. Respiration. 2019;98(5):401-409.
  9. Beuvon C, Coudroy R, Bardin J, et al. Respir Care. 2021;respcare.09242.
  10. Li J, Chen Y, Ehrmann S, Wu J, Xie L, Fink JB. Pharmaceutics. 2021;13(10):1655.
  11. Global Initiative for the Diagnosis, Management, and Prevention of Chronic Obstructive Lung Disease: 2023 report. Available at: https://goldcopd.org/2023-gold-report-2/ (accessed 06 December 2022).
  12. American Association for Respiratory Care SARS CoV-2 Guidance Document. https://www.aarc.org/wp-content/
  13. uploads/2020/03/guidance-document-SARS-COVID19.pdf (accessed 11 Nov 2022). 
  14. Fink JB, Ehrmann S, Li J, et al. J Aerosol Med Pulm Drug Deliv. 2020;33(6):300-304.
  15. Cinesi Gómez C, Peñuelas Rodríguez Ó, Luján Torné M, et al. Med Intensiva (Engl Ed). 2020;44(7):429-438.
  16. Respiratory care committee of Chinese Thoracic Society. Zhonghua Jie He He Hu Xi Za Zhi. 2020;17(0):E020.
  17. Kumar S, Mehta S, Sarangdhar N, et al. Expert Rev Respir Med. 2021;15(4):519-535.
  18. Swarnakar R, Gupta NM, Halder I, et al. Lung India. 2021;38(Supplement):S86-S91.
  19. Aerogen Data on File.

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