Help Centre: FAQs about Aerogen Ultra

Aerogen Ultra

Can both valved & open aerosol masks be used with Aerogen Ultra?

All standard aerosol masks can be connected to the Aerogen Ultra, but a valved mask (included) is best for optimal aerosol deposition 20. Use a flow rate of 1-6L/min with an open face mask and do not exceed 2L/min with a pediatric patient. Never use a closed face mask with the Aerogen Ultra.

Can a filter be used with the Aerogen Ultra to reduce emission of drugs?

Currently we do not have an approved filter which can be attached to the valved mouthpiece.

How do I clean the Aerogen Ultra?

The Aerogen Ultra is a single patient use device which is qualified for 20 intermittent use treatments (at a rate of four doses per day over 5 days) or 3 hours of continuous use. You can remove excess rainout from the Aerogen Ultra periodically (hourly with continuous nebulization). To ensure optimal performance of the Aerogen Ultra remove any residue by rinsing through with sterile water, shake off excess and allow to air dry.

How do you remove residue in the nebulization chamber after use of viscous drugs?

In order to remove any residues of viscous drugs you can nebulize a few drops of normal saline.

How long can I use the Aerogen Ultra?

The Aerogen Ultra is a single patient use device which is qualified for 20 intermittent use treatments (at a rate of four doses per day over 5 days) or 3 hours of continuous use.

What medications can the Aerogen Solo/ Ultra deliver?

The Aerogen Solo with Ultra can nebulize physician-prescribed medications for inhalation which are approved for use with a general purpose nebulizer. For more information on specific drugs and dosages please contact our Clinical team: In US/Canada : MedicalScience@aerogen.com or Rest of world: msl@aerogen.com

Can we use multiple types of drug in the same Aerogen Solo?

You don’t need a different Aerogen Solo to nebulise different drugs but when nebulising viscous drugs you may need to add a few drops of saline to clear the mesh before nebulising the next drug. Always refer to the drug manufacturer’s guidelines before combining drugs for nebulisation.

Should I adjust the drug dosage as I’m using the Aerogen Ultra?

The Aerogen Ultra can be used to nebulize all physician prescribed drugs approved for use with a general purpose nebulizer. Aerogen Ltd cannot provide specific advice on medication dose as it does not have regulatory approvals for drug/device combinations at this time. Information on drug dosing with specific nebulizers must be sourced from the manufacturer’s approved prescribing information for the inhaled formulation, bearing in mind published clinical research examining the efficiency of the different nebulizer technologies in terms of delivering therapeutic/effective drug levels in the lungs for specific medications. Should you require information regarding published clinical research for nebulization of specific medications with Aerogen’s devices then please contact our Clinical team directly at medicalscience@aerogen.com (US)/ Canada msl@aerogen.com (Rest of world).


It is recognised that physicians prescribe medications for nebulization that are not approved for use with a general purpose nebulizer based on their perceived clinical need and the risk: benefit ratio for the patient. This is classified as ‘off label’ use of those products and Aerogen Ltd cannot and does not promote ‘off label’ use of its devices.

How long does it take to deliver a unit dose?

The flow rate of the Aerogen Solo used with the Ultra is > 0.2ml/min with an average of 0.38ml/min. For a standard 3ml dose this would therefore take 7 minute 53 seconds13.

How much medication is left at the end of a treatment?

Medication left in the nebulizer at the end of the treatment is minimal: < 0.1mL13.

How much medication can be given at one time?

The medication cup of the Aerogen Solo nebulizer used with the Aerogen Ultra can hold up to 6mL of medication.

How does the lung deposition of drugs with the Aerogen Ultra compare to standard nebulizers?

Spontaneously breathing subjects showed six times greater deposition with the Aerogen Ultra compared to jet nebulizers17.

What evidence is available for why a valved mask as compared to a non-valved aerosol mask is optimal for use with the Ultra?

Ari et al., (2015) have shown that a valved mask will provide optimal aerosol dose to the patient compared to a standard open face mask. The aerosol dose is significantly improved with the valved facemask and also it is comparable to mouthpiece (comparison at 2L/min flow) 20.


13.Aerogen Solo System Instruction manual Aerogen Ltd. Part No. AG-AS3050 P/N 30-354. 17.Dugernier J, Hesse M, Vanbever R, Depoortere V, Roeseler J, Michotte JB, Laterre PF, Jamar F and Reychler G. SPECT-CT Comparison of Lung Deposition using a System combining a Vibrating-mesh Nebulizer with a Valved Holding Chamber and a Conventional Jet Nebulizer: a Randomized Cross-over Study. Pharmaceutical research. 2017;34:290-300. 20.Ari A, de Andrade AD, Sheard M, AlHamad B and Fink JB. Performance Comparisons of Jet and Mesh Nebulizers Using Different Interfaces in Simulated Spontaneously Breathing Adults and Children. Journal of aerosol medicine and pulmonary drug delivery. 2015;28:281-9.