All standard aerosol masks can be connected to the Aerogen Ultra, but a valved mask (included) is best for optimal aerosol deposition 20. Use a flow rate of 1-6L/min with an open face mask and do not exceed 2L/min with a pediatric patient. Never use a closed face mask with the Aerogen Ultra.
Currently we do not have an approved filter which can be attached to the valved mouthpiece.
The Aerogen Ultra is a single patient use device which is qualified for 20 intermittent use treatments (at a rate of four doses per day over 5 days) or 3 hours of continuous use. You can remove excess rainout from the Aerogen Ultra periodically (hourly with continuous nebulization). To ensure optimal performance of the Aerogen Ultra remove any residue by rinsing through with sterile water, shake off excess and allow to air dry.
In order to remove any residues of viscous drugs you can nebulize a few drops of normal saline.
The Aerogen Ultra is a single patient use device which is qualified for 20 intermittent use treatments (at a rate of four doses per day over 5 days) or 3 hours of continuous use.
The Aerogen Solo with Ultra can nebulize physician-prescribed medications for inhalation which are approved for use with a general purpose nebulizer. For more information on specific drugs and dosages please contact our Clinical team: In US/Canada : MedicalScience@aerogen.com or Rest of world: email@example.com
You don’t need a different Aerogen Solo to nebulise different drugs but when nebulising viscous drugs you may need to add a few drops of saline to clear the mesh before nebulising the next drug. Always refer to the drug manufacturer’s guidelines before combining drugs for nebulisation.
The Aerogen Ultra can be used to nebulize all physician prescribed drugs approved for use with a general purpose nebulizer. Aerogen Ltd cannot provide specific advice on medication dose as it does not have regulatory approvals for drug/device combinations at this time. Information on drug dosing with specific nebulizers must be sourced from the manufacturer’s approved prescribing information for the inhaled formulation, bearing in mind published clinical research examining the efficiency of the different nebulizer technologies in terms of delivering therapeutic/effective drug levels in the lungs for specific medications. Should you require information regarding published clinical research for nebulization of specific medications with Aerogen’s devices then please contact our Clinical team directly at firstname.lastname@example.org (US)/ Canada email@example.com (Rest of world).
It is recognised that physicians prescribe medications for nebulization that are not approved for use with a general purpose nebulizer based on their perceived clinical need and the risk: benefit ratio for the patient. This is classified as ‘off label’ use of those products and Aerogen Ltd cannot and does not promote ‘off label’ use of its devices.
The flow rate of the Aerogen Solo used with the Ultra is > 0.2ml/min with an average of 0.38ml/min. For a standard 3ml dose this would therefore take 7 minute 53 seconds13.
Medication left in the nebulizer at the end of the treatment is minimal: < 0.1mL13.
The medication cup of the Aerogen Solo nebulizer used with the Aerogen Ultra can hold up to 6mL of medication.
Spontaneously breathing subjects showed six times greater deposition with the Aerogen Ultra compared to jet nebulizers17.
Ari et al., (2015) have shown that a valved mask will provide optimal aerosol dose to the patient compared to a standard open face mask. The aerosol dose is significantly improved with the valved facemask and also it is comparable to mouthpiece (comparison at 2L/min flow) 20.
13.Aerogen Solo System Instruction manual Aerogen Ltd. Part No. AG-AS3050 P/N 30-354. 17.Dugernier J, Hesse M, Vanbever R, Depoortere V, Roeseler J, Michotte JB, Laterre PF, Jamar F and Reychler G. SPECT-CT Comparison of Lung Deposition using a System combining a Vibrating-mesh Nebulizer with a Valved Holding Chamber and a Conventional Jet Nebulizer: a Randomized Cross-over Study. Pharmaceutical research. 2017;34:290-300. 20.Ari A, de Andrade AD, Sheard M, AlHamad B and Fink JB. Performance Comparisons of Jet and Mesh Nebulizers Using Different Interfaces in Simulated Spontaneously Breathing Adults and Children. Journal of aerosol medicine and pulmonary drug delivery. 2015;28:281-9.