Help Centre

Aerogen Ultra


Can both valved and open aerosol masks be used with Aerogen Ultra?

Aerogen Ultra connects with all standard aerosol masks – the valved mask, which comes included, is best for optimal aerosol deposition.20 Use a flow rate of 1-6L/min with an open face mask and do not exceed 2L/min with a paediatric patient. NOTE: Never use a closed face mask with Aerogen Ultra.




Can a filter be used with Aerogen Ultra to reduce emission of drugs?

We do not currently have an approved filter that can be attached to the valved mouthpiece.




How do I clean Aerogen Ultra?

Aerogen Ultra is a single-patient-use device that is qualified for 20 intermittent use treatments (at a rate of four doses per day over 5 days) or 3 hours of continuous use. You should periodically remove excess rainout from the Aerogen Ultra (we suggest that you do this hourly when nebulisation is continuous). To ensure optimal Aerogen Ultra performance, remove any residue by rinsing through with sterile water, shaking off excess and allowing the device to air-dry.




How do you remove residue in the nebulisation chamber after use of viscous drugs?

You can nebulise a few drops of normal saline to remove any residues of viscous drugs.




For how long can I use Aerogen Ultra?

Aerogen Ultra is a single-patient-use device which is qualified for 20 intermittent use treatments (at a rate of four doses per day over 5 days) or 3 hours of continuous use.




What medications can Aerogen Ultra deliver?

Used with Aerogen Solo, Aerogen Ultra can nebulise physician-prescribed medications for inhalation which are approved for use with a general purpose nebuliser. For more information on specific drugs and dosages please contact our Clinical Team. In US/Canada: MedicalScience@aerogen.com, Rest of World: msl@aerogen.com




Can we use multiple types of drug in the same Aerogen Solo/Ultra?

You don’t need a different Aerogen Solo to nebulise different drugs. However, when nebulising viscous drugs, you may need to add a few drops of saline to clear the mesh before nebulising the next drug. Always refer to the drug manufacturer’s guidelines before combining drugs for nebulisation.




Should I adjust the drug dosage as I’m using Aerogen Ultra?

Aerogen Ultra can be used to nebulise all physician-prescribed drugs approved for use with a general purpose nebuliser. Aerogen Ltd cannot provide specific advice on medication dose as it does not have regulatory approvals for drug/device combinations at this time. Information on drug dosing with specific nebulisers must be sourced from the manufacturer’s approved prescribing information for the inhaled formulation. Bear in mind published clinical research examining the efficiency of the different nebulizer technologies in terms of delivering therapeutic/effective drug levels in the lungs for specific medications. Should you require information regarding published clinical research for nebulisation of specific medications with Aerogen devices, please contact our Clinical Team directly at medicalscience@aerogen.com (US)/ Canada or msl@aerogen.com (Rest of World).

It is recognised that physicians prescribe medications for nebulisation that are not approved for use with a general purpose nebuliser based on their perceived clinical need and the Risk:Benefit ratio for the patient. This is classified as ‘off label’ use of those products and Aerogen Ltd cannot and does not promote ‘off label’ use of its devices.




How long does it take to deliver a unit dose?

The flow rate of Aerogen Solo used with Aerogen Ultra is > 0.2ml/min with an average of 0.38ml/min. Thus, a standard 3ml dose takes 7 minutes, 53 seconds to deliver.13




How much medication is left at the end of a treatment?

Medication left in the nebuliser at the end of the treatment is minimal: < 0.1mL.13




How much medication can be given at one time?

The Aerogen Solo medication cup used with Aerogen Ultra can hold up to 6mL of medication.




How does Aerogen Ultra perform in comparison to standard nebulisers in terms of lung deposition of drugs?

Spontaneously breathing subjects showed 6X greater lung deposition with Aerogen Ultra compared to jet nebulisers.17




What evidence is available for why a valved mask rather than a non-valved aerosol mask is optimal for use with Aerogen Ultra?

Ari et al., (2015) have shown that a valved mask will provide optimal aerosol dose to the patient compared to a standard open face mask. The aerosol dose is significantly improved with the valved facemask and is comparable to mouthpiece dose (comparison at 2L/min flow).20



References

13.Aerogen Solo System Instruction manual Aerogen Ltd. Part No. AG-AS3050 P/N 30-354. 17.Dugernier J, Hesse M, Vanbever R, Depoortere V, Roeseler J, Michotte JB, Laterre PF, Jamar F and Reychler G. SPECT-CT Comparison of Lung Deposition using a System combining a Vibrating-mesh Nebulizer with a Valved Holding Chamber and a Conventional Jet Nebulizer: a Randomized Cross-over Study. Pharmaceutical research. 2017;34:290-300. 20.Ari A, de Andrade AD, Sheard M, AlHamad B and Fink JB. Performance Comparisons of Jet and Mesh Nebulizers Using Different Interfaces in Simulated Spontaneously Breathing Adults and Children. Journal of aerosol medicine and pulmonary drug delivery. 2015;28:281-9.