Help Centre: FAQs about Aerogen Solo

Aerogen Solo

What brands or models of ventilators can use the Aerogen Solo?

The Aerogen Solo can be used with any brand or model of ventilator. Aerogen technology is integrated in ventilators made by Hamilton Medical, Maquet, Dräger, Resmed, Philips and GE Healthcare.

How long does it take to deliver a unit dose?

The flow rate of the Aerogen Solo is > 0.2ml/min with an average of 0.38ml/min. For a standard 3ml dose this would therefore take 7 minute 53 seconds13.

How much medication is left at the end of a treatment?

Medication left in the nebulizer at the end of the treatment is minimal: < 0.1mL13.

How much medication can be given at one time?

The medication cup can hold up to 6mL of medication.

Can the Aerogen Solo be used with a mouthpiece and an aerosol mask?

Yes, the Aerogen Solo can be connected to the Aerogen Ultra and used with a mouthpiece or aerosol mask (mouthpiece and valved aerosol mask can be provided).

How quiet is the Aerogen Solo?

The Aerogen Solo is virtually silent. The noise level is less than 35dB measured at 0.3m distance.

How do I clean the Aerogen Solo?

The Aerogen Solo is a single patient use device and can be used for up to 28 days inline on a ventilator circuit based on a typical usage of 4 intermittent treatments per day. For continuous use, the Aerogen Solo is qualified for a maximum of 7 days. Nebulizing a few drops of normal saline can remove any drug residue between doses (which can occur occasionally with viscous drugs). The Aerogen Solo should not be removed from the patient circuit for cleaning.

How do you remove residue in the chamber after nebulization of viscous drugs?

In order to remove any residue of viscous drugs, you can nebulize a few drops of normal saline.

What medications can the Aerogen Solo deliver?

The Aerogen Solo can nebulize physician-prescribed medications for inhalation which are approved for use with a general purpose nebulizer. For more information on specific drugs and dosages please contact our Clinical team: medicalscience@aerogen.com (US)/ msl@aerogen.com (Rest of world).

Can we use multiple types of drug in the same Aerogen Solo?

You don’t need a different Aerogen Solo to nebulise different drugs, but when nebulising viscous drugs you may need to add a few drops of saline to clear the mesh before nebulising the next drug. Always refer to the drug manufacturer’s guidelines before combining drugs for nebulisation.

Should I adjust the drug dosage as I’m using the Aerogen Solo?

Aerogen Ltd cannot provide specific advice on medication dose as it does not have regulatory approvals for drug/device combinations at this time. Information on drug dosing with specific nebulizers must be sourced from the manufacturer’s approved prescribing information for the inhaled formulation, bearing in mind published clinical research examining the efficiency of the different nebulizer technologies in terms of delivering therapeutic/effective drug levels in the lungs for specific medications. Should you require information regarding published clinical research for nebulization of specific medications with Aerogen’s devices then please contact our Clinical team directly at medicalscience@aerogen.com (US)/Canada msl@aerogen.com (Rest of world).
It is recognised that physicians prescribe medications for nebulization that are not approved for use with a general purpose nebulizer based on their perceived clinical need and the risk: benefit ratio for the patient. This is classified as ‘off label’ use of those products and Aerogen Ltd cannot and does not promote ‘off label’ use of its devices.

How long can you use the Aerogen Solo?

The Aerogen Solo is a single patient use device and can be used for 28 days based on a typical usage of 4 intermittent treatments per day. For continuous use, the Aerogen Solo is qualified for a maximum of 7 days.

How does the lung deposition of drugs with the Aerogen Solo compare to standard nebulizers?

The Aerogen Solo provides 10-15% lung deposition compared to standard jet nebulizer (3%) during mechanical ventilation14, 15. Nearly four times more is delivered with Aerogen during NIV16. Also, using the Aerogen Ultra, spontaneously breathing subjects showed six times greater deposition compared to jet nebulizers17.

What should I do if the Aerogen Solo stops nebulizing?

Please refer to the trouble shooting guide in the directions for use.

How do I get replacement parts?

Contact your local Aerogen Solo Distributor.

What should I do if the expiratory filter becomes saturated causing the ventilator to alarm following nebulisation?

This can happen on rare occasions. If the Aerogen Solo is positioned near the wye then moving it back to the humidifier will result in less aerosol reaching the expiratory filter (which may resolve the problem) and more drug being delivered to the patient. Occluded filters should be replaced with a new filter and changed according to manufacturer recommendations and as needed.

Can Aerogen be sent home with patients?

The Aerogen Solo can be used at home for patient’s requiring any type of ventilator support using the Aerogen USB controller. For spontaneous breathing patients, the InnoSpire Go is available from Philips and utilises the same Aerogen vibrating mesh technology.

Can the Aerogen Solo be used during Non-Invasive Ventilation?

Placement of the Aerogen Solo during non-invasive ventilation (BIPAP/CPAP) is improved when the nebulizer is placed between the fixed leak in the circuit and the patient. A bench study by Abdelrahim et al. (2010) demonstrated that aerosol delivery is higher between the leak and the mask. The Aerogen device delivered twice as much aerosol as compared to a standard jet nebulizer 18.

When using non-invasive ventilation with a critical care ventilator (dual limb) you can position the nebuliser on the dry side of the humidifier, at the wye- piece or at the mask. Velasco et al. (2018) reported in a pediatric model that the aerosol dose was significantly higher if the Aerogen Solo was placed at the wye or mask however acceptable levels were still noted at the dry side of the humidifier19.


13.Aerogen Solo System Instruction manual Aerogen Ltd. Part No. AG-AS3050 P/N 30-354. 17.Dugernier J, Hesse M, Vanbever R, Depoortere V, Roeseler J, Michotte JB, Laterre PF, Jamar F and Reychler G. SPECT-CT Comparison of Lung Deposition using a System combining a Vibrating-mesh Nebulizer with a Valved Holding Chamber and a Conventional Jet Nebulizer: a Randomized Cross-over Study. Pharmaceutical research. 2017;34:290-300. 18.Abdelrahim ME, Plant P and Chrystyn H. In-vitro characterisation of the nebulized dose during non-invasive ventilation. The Journal of pharmacy and pharmacology. 2010;62:966-72. 19.Velasco J and Berlinski A. Albuterol Delivery Efficiency in a Pediatric Model of Noninvasive Ventilation With Double-Limb Circuit. Respiratory care. 2018;63:141-146.