The Aerogen Solo can be used with any brand or model of ventilator. Aerogen technology is integrated in ventilators made by Hamilton Medical, Maquet, and GE Healthcare.
The flow rate of the Aerogen Solo is > 0.2ml/min with an average of 0.38ml/min. For a standard 3ml dose this would therefore take 7 minute 53 seconds13.
Medication left in the nebuliser at the end of the treatment is minimal: < 0.1mL13.
The medication cup can hold up to 6mL of medication.
Yes, the Aerogen Solo can be connected to the Aerogen Ultra and used with a mouthpiece or aerosol mask.
The Aerogen Solo is virtually silent. The noise level is less than 35dB measured at 0.3m distance.
The Aerogen Solo is a single patient use device and can be used for up to 28 days inline on a ventilator circuit based on a typical usage of 4 intermittent treatments per day. For continuous use, the Aerogen Solo is qualified for a maximum of 7 days. Nebulising a few drops of normal saline can remove any drug residue between doses (which can occur occasionally with viscous drugs). The Aerogen Solo should not be removed from the patient circuit for cleaning.
In order to remove any residue of viscous drugs, you can nebulise a few drops of normal saline.
The Aerogen Solo can nebulise physician-prescribed medications for inhalation which are approved for use with a general purpose nebuliser. For more information on specific drugs and dosages please contact our Clinical team: firstname.lastname@example.org (US)/ email@example.com (Rest of world).
You don’t need a different Aerogen Solo to nebulise different drugs, but when nebulising viscous drugs you may need to add a few drops of saline to clear the mesh before nebulising the next drug. Always refer to the drug manufacturer’s guidelines before combining drugs for nebulisation.
The Aerogen Solo is a single patient use device and can be used for 28 days based on a typical usage of 4 intermittent treatments per day. For continuous use, the Aerogen Solo is qualified for a maximum of 7 days.
The Aerogen Solo provides 10-15% lung deposition compared to standard jet nebuliser (3%) during mechanical ventilation15, 16. Nearly four times more is delivered with Aerogen during NIV17. Also, using the Aerogen Ultra, spontaneously breathing subjects showed six times greater deposition compared to jet nebulisers18.
Please refer to the trouble shooting guide in the directions for use.
Contact your local Aerogen Solo Distributor. (Refer to https://www.aerogen.com/distributors/)
This can happen on rare occasions. If the Aerogen Solo is positioned near the wye then moving it back to the humidifier will result in less aerosol reaching the expiratory filter (which may resolve the problem) and more drug being delivered to the patient. Occluded filters should be replaced with a new filter and changed according to manufacturer recommendations and as needed.
The Aerogen Solo can be used at home for patients requiring any type of ventilator support using the Aerogen USB controller. For spontaneous breathing patients, the InnoSpire Go is available from Philips and utilises the same Aerogen vibrating mesh technology.
Placement of the Aerogen Solo during non-invasive ventilation (BIPAP/CPAP) is improved when the nebuliser is placed between the fixed leak in the circuit and the patient. A bench study by Abdelrahim et al. (2010) demonstrated that aerosol delivery is higher between the leak and the mask. The Aerogen device delivered twice as much aerosol as compared to a standard jet nebuliser 18.
When using non-invasive ventilation with a critical care ventilator (dual limb) you can position the nebuliser on the dry side of the humidifier, at the wye- piece or at the mask. Velasco et al. (2018) reported in a pediatric model that the aerosol dose was significantly higher if the Aerogen Solo was placed at the wye or mask however acceptable levels were still noted at the dry side of the humidifier19.
Rain-out in the circuit due to aerosol delivery via the Aerogen Solo should be minimal. Placement back on the dry (ventilator) side of the humidifier may reduce rain-out because the large aerosol particles could rain-out in the humidifier chamber versus in the circuit. The amount of aerosol delivery over time will affect the amount of rain-out produced.
No. The placement of the Aerogen Solo and the T-piece is a matter of choice for the healthcare provider, however, it is important to note that the placement of the T-piece between the wye ant the ET tube will increase the dead space volume. It will also add to increased weight of the circuit.
Please refer to the Ventilator Instructions for Use.
Please note that Aerogen products are not approved for use with neonates within the USA.
Any aerosol added to a ventilator circuit could potentially affect the expiratory flow sensor and expiratory filter as moisture in the circuit is increased. Expiratory Flow flow sensors can be adversely affected especially in certain ventilators. More aerosol in the circuit can cause the expiratory ventilator filters to become saturated more quickly and increase the resistance to exhalation. Filters should be monitored as well as patient expiratory resistance. Changing the filters may be required on a regular basis. Please consult the relevant Ventilator Manufacturers (IFU) Instructions for Use Manuals, for filter specific requirements.
An expiratory filter should always be in line to protect the internal mechanisms in the ventilator and change the expiratory filter as needed. Viscous medications may require more frequent filter changes. Please consult the relevant Ventilator Manufacturer’s (IFU) Instructions for Use Manuals, for filter specific requirements.
Although the research does show that there is better aerosol delivery closer to the patient in a neonatal circuit, it is also important to note that there is still adequate aerosol delivery associated with the Aerogen Solo at the ventilator. Berlinski et al. (2016) demonstrated between 8.2 and 9.5% deposition with the Aerogen Solo placed back at the ventilator in a neonatal mechanical ventilation model22. This should be more than enough to be clinically significant in an infant.
Clinicians may prefer to place the nebuliser on the dry side of the humidifier for a variety of reasons including less rainout at the wye, less aerosol on the flow sensor and it may eliminate the problem of added weight which could result in accidental extubation.
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