Help Centre

Aerogen Solo

With which brands/models of ventilators can I use Aerogen Solo?

Aerogen Solo can be used with any brand or model of ventilator. Aerogen technology is integrated in ventilators made by Hamilton Medical, Maquet, Dräger, Resmed, Philips and GE Healthcare.

How long does it take to deliver a unit dose?

The flow rate of the Aerogen Solo is > 0.2ml/min with an average of 0.38ml/min. Thus, a standard 3ml dose takes 7 minutes, 53 seconds to deliver.13

How much medication is left at the end of a treatment?

Medication left at the end of the treatment is minimal: < 0.1mL.13

How much medication can be given at one time?

The medication cup can hold up to 6mL of medication.

Can Aerogen Solo be used with a mouthpiece and an aerosol mask?

Yes, by connecting Aerogen Solo with Aerogen Ultra you can deliver treatment via mouthpiece or aerosol mask (mouthpiece and valved aerosol mask can be provided).

How quiet is Aerogen Solo?

The Aerogen Solo is virtually silent. The noise level is less than 35dB measured at 0.3m distance.

How do I clean Aerogen Solo?

Aerogen Solo is a single-patient-use device and can be used for up to 28 days inline on a ventilator circuit, based on a typical usage of 4 intermittent treatments per day. For continuous use, Aerogen Solo is qualified for a maximum of 7 days. Nebulising a few drops of normal saline can remove any drug residue between doses (which can occur occasionally with viscous drugs). Aerogen Solo should not be removed from the patient circuit for cleaning.

How do I remove residue in the chamber after nebulisation of viscous drugs?

In order to remove any residue of viscous drugs, simply nebulise a few drops of normal saline.

What medications can Aerogen Solo deliver?

Aerogen Solo can nebulise physician-prescribed medications for inhalation which are approved for use with a general purpose nebuliser. For more information on specific drugs and dosages please contact our Clinical Team: (US) / (Rest of World).

Can we use multiple types of drug in the same Aerogen Solo?

You don’t need a different Aerogen Solo to nebulise different drugs, but when nebulising viscous drugs you may need to add a few drops of saline to clear the mesh before nebulising the next drug. Always refer to the drug manufacturer’s guidelines before combining drugs for nebulisation.

Should I adjust the drug dosage as I’m using the Aerogen Solo?

Aerogen Ltd cannot provide specific advice on medication dose as it does not have regulatory approvals for drug/device combinations at this time. Information on drug dosing with specific nebulizers must be sourced from the manufacturer’s approved prescribing information for the inhaled formulation. Bear in mind published clinical research examining the efficiency of different nebuliser technologies in terms of delivering therapeutic/effective drug levels in the lungs for specific medications. Should you require information regarding published clinical research for nebulisation of specific medications with Aerogen devices, please contact our Clinical team directly at (US)/Canada (Rest of World).

It is recognised that physicians prescribe medications for nebulisation that are not approved for use with a general purpose nebuliser based on their perceived clinical need and the Risk: Benefit ratio for the patient. This is classified as ‘off label’ use of those products and Aerogen Ltd cannot and does not promote ‘off label’ use of its devices.

For how long can you use an Aerogen Solo?

Aerogen Solo is a single-patient-use device and can be used for 28 days based on a typical usage of 4 intermittent treatments per day. If used in continuous mode, Aerogen Solo is qualified for a maximum of 7 days.

How does Aerogen Solo compare to standard nebulisers in terms of lung deposition of drugs?

Aerogen Solo provides 10-15% lung deposition compared to a standard jet nebuliser (3%) during mechanical ventilation.14, 15 Nearly four times more is delivered with Aerogen during NIV.16 In tests using Aerogen Ultra, spontaneously breathing subjects received 6X greater lung deposition compared to patients using a jet nebuliser.17

What should I do if Aerogen Solo stops nebulising?

Please refer to the troubleshooting guide in our Directions for Use.

How do I get replacement parts?

Please contact your local Aerogen distributor.

What should I do if the expiratory filter becomes saturated causing the ventilator to alarm following nebulisation?

This can happen on rare occasions. If Aerogen Solo is positioned near the wye, moving it back to the humidifier will result in less aerosol reaching the expiratory filter (which may resolve the problem) and more drug being delivered to the patient. Occluded filters should be replaced with a new filter and changed according to manufacturer recommendations and as needed.

Can Aerogen devices be sent home with patients?

Aerogen Solo can be used at home with an Aerogen USB controller for patients who require any type of ventilator support. For spontaneous breathing patients, the InnoSpire Go, available from Philips, utilises the same Aerogen vibrating mesh technology.

Can Aerogen Solo be used during Non-Invasive Ventilation?

Placement of Aerogen Solo during non-invasive ventilation (BiPAP/CPAP) is improved when the nebuliser is placed between the fixed leak in the circuit and the patient. A bench study by Abdelrahim et al. (2010) demonstrated that aerosol delivery is higher between the leak and the mask. The Aerogen device delivered twice as much aerosol compared to a standard jet nebuliser.18

When using non-invasive ventilation with a critical care ventilator (dual limb) you can position the nebuliser on the dry side of the humidifier, at the wye-piece, or at the mask. Velasco et al. (2018) reported in a paediatric model that the aerosol dose was significantly higher if Aerogen Solo was placed at the wye or mask, however acceptable levels were also noted at the dry side of the humidifier.19


13.Aerogen Solo System Instruction manual Aerogen Ltd. Part No. AG-AS3050 P/N 30-354. 14.MacIntyre NR, Silver RM, Miller CW, Schuler F and Coleman RE. Aerosol delivery in intubated, mechanically ventilated patients. Critical care medicine. 1985;13:81-4. 15.Dugernier J, Reychler G, Wittebole X, Roeseler J, Depoortere V, Sottiaux T, Michotte JB, Vanbever R, Dugernier T, Goffette P, Docquier MA, Raftopoulos C, Hantson P, Jamar F and Laterre PF. Aerosol delivery with two ventilation modes during mechanical ventilation: a randomized study. Annals of intensive care. 2016;6:73. 16.Galindo-Filho VC, Ramos ME, Rattes CS, Barbosa AK, Brandão DC, Brandão SCS, Fink JB and Dornelas de Andrade A. Radioaerosol Pulmonary Deposition Using Mesh and Jet Nebulizers During Noninvasive Ventilation in Healthy Subjects. Respiratory care. 2015;60:1238-1246. 17.Dugernier J, Hesse M, Vanbever R, Depoortere V, Roeseler J, Michotte JB, Laterre PF, Jamar F and Reychler G. SPECT-CT Comparison of Lung Deposition using a System combining a Vibrating-mesh Nebulizer with a Valved Holding Chamber and a Conventional Jet Nebulizer: a Randomized Cross-over Study. Pharmaceutical research. 2017;34:290-300. 18.Abdelrahim ME, Plant P and Chrystyn H. In-vitro characterisation of the nebulised dose during non-invasive ventilation. The Journal of pharmacy and pharmacology. 2010;62:966-72. 19.Velasco J and Berlinski A. Albuterol Delivery Efficiency in a Pediatric Model of Noninvasive Ventilation With Double-Limb Circuit. Respiratory care. 2018;63:141-146.