Aeroneb Lab
The Aeroneb® Lab Nebulizer is a high-efficiency nebulizer for use in preclinical aerosol research and inhalation studies. The Aeroneb Lab provides a valuable link between preclinical and clinical drug development research for compounds targeted for delivery through the lungs.
Using Aerogen’s OnQ™ technology, the Aeroneb Lab is designed to produce a highly respirable aerosol from virtually any drug in liquid format, without altering or damaging the compound’s molecular integrity or altering its concentration.
The Aeroneb Lab is available in 2 formats, a standard VMD nebulizer (4.0 µm - 6.0 µm ) and a small VMD nebulizer (2.5 µm – 4.0 µm) for use with preclinical models of various sizes.
Aeroneb Lab Efficiency
Representative lung scintigraphy after aerosolization of 30 µL containing 2mCi of 99 mTc-DTPA with the Aeroneb Lab in a preclinical infant model of mechanical ventilation with a 2 kg macaque. (Mean deposition 12.3 ± 4.1%, n=4)
Aeroneb Lab Efficient
Produces a high quality aerosol (precise particle size with low GSD)
Low residual volume minimizes drug waste ( <0.1mL)
OnQ does not alter formulation’s molecular integrity
Flexible
Aerosolizes a broad range of liquid formations without altering molecular integrity
Two particle size options maximize utility across a range of test species and test conditions
Provides a bridge from preclinical to clinical studies
Proven
Utilizes the same OnQ technology used in proven commercial and research nebulizer products.
Published studies have demonstrated successful aerosolization of a variety of drugs in solution or suspension, including gene therapy vector¹ (rAAV) and the recombinant fusion protein² (Epo-Fc).
¹Wilson L, Simmons R, Uster P. Aerosol Characteristics of Adeno-Associated Viral Vectors Produced by an Electronic Micropump Inhaler. CFF 2003
²Clark D, Pickford M, Evans S, Bitoni A, Newman S. Targeting an Inhaled Erythropoietin-Fc Fusion Protein (Epo-Fc) to the Human Large Central Airwards. ISAM 2003.
Product Specifications:
Physical:
Nebulizer Unit dimensions: 45mm H x 50mm W x 50mm D
Control Module dimensions: 33mm H x 75mm W x 131mm D
Control Module cable: 1.8m long
Nebulizer Unit weight: 25g nebulizer unit and filter cap
Control Module weight: 178g including cable
Nebulizer Unit capacity: maximum 10mL
Nebulizer and Nebulizer and components do not contain natural rubber latex.
Performance
Standard Volume Median Diameter (VMD) Nebulizer Unit
Flow rate: >0.3mL/min
Particle size: VMD between 4.0μm and 6.0μm
Residual volume: <0.1mL
Small Volume Median Diameter (VMD) Nebulizer Unit
Flow rate: >0.1mL/min
Particle size: VMD between 2.5μm and 4.0μm
Residual volume: <0.1mL
Power
Power source: can operate from AC/DC adapter (input 100 to 240VAC 50 – 60Hz, output 9V) OR an external 9V DC power supply Power consumption: ≤2.57 Watts
